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KMID : 0378019910340110103
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New Medical Journal
1991 Volume.34 No. 11 p.103 ~ p.110
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Behaviour of free amino acids in plasma and urine of polytraumatized & postop. intensive care patients under the supply of an amino acid solution containing 10% branched chain amino acids.(Intrafusin^(®))
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유환국/Yoo, H.K.
최병철/이섭/안욱수/이정호/Choi, B.C./Lee, S./Ahn, W.S./Lee, J.H.
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Abstract
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Numerous recent experimental works showed the behavior of branched chain amino acids in plasma and the abnormalities found in postoperative and post-traumatic catabolic´ state. high concentration of BCAAs in plasma is inadequate for protein anabolism. The amino acid imbalance and antagonism in plasma increases amino acid requirement and delaying the wound healing. so in order to optimize amino acid utilization these should be supplied in proportions rather than in quantity.
This study was designed to evaluate the behavior of the concentration and metabolism of amino acids in plasma and urine of postoperative and poly-traumatized intensive care patients under the supply of an amino acid solution containing low concentration(10%) branched chain amino acids(lntratusin®).
The results were summarized as follows
1. Twenty postoperative and post traumatc patients were selected under the basis of the duration of assisted ventilation(more than three days).
2. The mean age was 27 y-o. mean height was 160cm, and mean weight was 55kg. 3. 13 were male and 7 were female.
4. Standardized parenteral nutrition mixture. consisting of 1gm amino acid/kg BW and day and 6.4-gm carbohydrates/kg and day were supplied.
5. The total amino acid concentration in plasma was low initially but increased constantly up
to the third day and remained continuously at about same level.
6. The branched chain amino acids acids behaved in the same way as the total amino acid concentration.
7. The glutamine concentration was remained unchanged within the reference range.
8. A temporary increase in alanine concentration occurred and then decreased continuously.
9. The excretion of nitrogen and free amino acids increased continuously.
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KEYWORD
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